second malignancy การใช้

• In this study, second malignancies accounted for 41 % of deaths, and heart disease, 29 %.
• Most deaths following remission are from other causes, such as second malignancies, which in one study occurred in 8 % of patients.
• Its goal is to diminish the long-term effects of cancer treatment, including second malignancies, and to introduce healthy lifestyle changes to patients who have survived cancer.
• Currently Dexrazoxane is the only FDA / EMA approved agent for preventing anthracycline-induced cardiotoxicity which according to Ewer & Speyer'must become an essential part of anthracycline-based modern chemotherapy practice'allowing for the optimization of anthracycline-based treatment modalities in adult and pediatric oncology without enhancing second malignancies.
• Prophylactic cranial irradiation for acute lymphoblastic leukemia ( ALL ) is technically adjuvant, and most experts agree that cranial irradiation decreases risk of central nervous system ( CNS ) relapse in ALL and possibly acute myeloid leukemia ( AML ), but it can cause severe side effects, and adjuvant intrathecal methotrexate and hydrocortisone may be just as effective as cranial irradiation, without severe late effects, such as developmental disability, dementia, and increased risk for second malignancy.